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2000, 72: 653S-669S

The demonstrated restructuring effects of SGLT2 inhibitors on gut microbial community architecture and their regulatory actions on metabolite generation (156) may confound the authenticity of associations between metabolites and disease

The complicated ROS elimination system comprises endogenous antioxidant enzymes, mainly including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as low-molecular-weight scavengers, including vitamins, -carotene, coenzyme Q, selenium and zinc

It was demonstrated that the molecular determinant(s) unifying these phenomena, was related to GSH and GSH-sensitive molecular factors

Isgs such as Isg15, interferon alpha inducible protein (Ifi)27l2a, interferon-induced protein with tetratricopeptide repeats (Ifit)1, Ifit2 and Ifit3 were increased, and Isg20, interferon induced transmembrane protein (Ifitm)1, Ifitm2, Ifitm3 were decreased in the CD8 + T cells of high glucose drink group